Cell Symposia

Official Conference #Hashtag: #immunometabolism
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The obesity epidemic is fuelling the need to understand how metabolic imbalance drives disease pathogenesis. It is now widely recognized that obesity impacts the immune system and that obesity-associated inflammation contributes to metabolic diseases, such as Type 2 diabetes and cardiovascular disease, as well as cancer.

The aim of this meeting is to bring together researchers from the arenas of immunology and metabolism to discuss the cell types, mediators and pathways that contribute to immunological-metabolic crosstalk and to explore how the immune system might be targeted as a strategy to treat metabolic disease.


(Subject to change)

Sunday, June 9, 2013
13:30–15:45 Registration Civic Foyer
15.45–16.00 Welcome and Introduction Civic Ballroom South
Session I: Inflammatory Pathways and Metabolic Disease
(Session Chair - TBD) 
 | Civic Ballroom South 
16:00–16:45 [K1] Keynote: Mechanisms of immunometabolic integration In obesity and diabetes
Gökhan Hotamisligil, Harvard Medical School, USA
16:45–17:15 [K2] Metabolic regulation of innate immune signalling
Luke O'Neill, Trinity College Dublin, Ireland
17:15–17:30 [O1] Lipid-induced muscle-macrophage crosstalk contributes to insulin resistance
A. Klip, The Hospital for Sick Children, Canada
17:30–18.00 Refreshment break Simcoe & Dufferin Room and Civic Ballroom North  
18.00–18:30 [K3] Inflammation and metabolism
Ruslan Medzhitov, Yale University, USA
18:30–19:00 [K4] Hypothalamic Inflammation and the Metabolic Syndrome
Matthias Tschöp, Technical University Munich, Germany
19:15–20:15 Drinks ReceptionCivic Foyer & Garden Waterfall
Monday, June 10, 2013
Session II: Metabolic Programming of Systemic Immunity
(Session Chair- Marc Donath) | Civic Ballroom South
9:30–10:00 [K6] Virchow explained: The origin of tumor-elicited inflammation and its significance
Michael Karin, University of California, San Diego, USA
10:00–10:15 [O2] Obesity-associated autoantibody production requires AIM to retain IgM immune complex on follicular dendritic cells
S. Arai, The University of Tokyo, Japan
10:15–10:45 Refreshment Break | Simcoe & Dufferin Room and Civic Ballroom North
10:45–11:15 [K7] Targeting gp130 to prevent inflammation and promote insulin action
Mark Febbraio, Baker IDI Heart and Diabetes Institute, Australia                                                                                             
11:15–11.45 [K8] A reversible mechanism of age-related mitochondrial dysfunction and inflammation
David Sinclair, Harvard Medical School, USA
12:00 - 13:00 Lunch | Civic Foyer
13:00 - 15:00 Poster session I | Simcoe & Dufferin Room and Civic Ballroom North
Session III – Metabolic-immune Cell Interactions
(Session Chair - TBD) | Civic Ballroom South
15:00–15:30 [K9] Regulatory T cells residing in adipose tissue
Diane Mathis (co-organizer), Harvard Medical School, USA         
15:30–16:00 [K10] Innate lymphoid type 2 cells (ILC2) and the cellular architecture of visceral adipose tissue
Richard Locksley, University of California San Francisco, USA
16:00–16:15 [O3] Class II major histocompatibility complex plays an essential role in obesity-induced adipose inflammation
T. Deng, The Methodist Hospital Research Institute, USA
16:15 - 16:45 Refreshments | Simcoe & Dufferin Room and Civic Ballroom North
16:45–17:15 [K12] Brown and beige fat: basic biology, inflammation and novel therapeutics
Bruce Spiegelman, Dana-Faber Cancer Institute, USA
17:15–17:30 Short talk TBD
19.00 "Meet the Speakers” Dinner (ticket holders only )
Tuesday 11th June
Session IV – Nutrients and Gut Microbiota
(Session Chair- Diane Mathis) | Civic Ballroom South
9:00 - 9:30 [K13] Diet rapidly and reproducibly alters the human gut microbiome
Peter Turnbaugh, Harvard University, USA
9:30–10:00 [K14] Pathways in microbe-induced obesity
Martin Blaser, New York University, USA
10:00–10:15 [O4] Diet-microbiota interactions and their implication for host metabolism
R. Caesar, Gothenburg University, Sweden
10:15–10:45 Refreshment break | Simcoe & Dufferin Room and Civic Ballroom North
10:45–11:15 [K15] Inflammasomes regulate the development of obesity and insulin resistance through modulation of intestinal microbiota
Richard Flavell, Yale University, USA
11:15 - 11:30 [O5] A SIRT1-RelB checkpoint reprograms mitochondrial bioenergetics during acute inflammation
T.F. Liu, Wake Forest University School of Medicine, USA
11:30–11:45 [O6] High fat diet leads to activation of myeloid progenitors
K. Singer, University of Michigan, USA
12:00 - 13:00 Lunch | Civic Foyer
13:00 - 15:00 Poster Session II | Simcoe & Dufferin Room and Civic Ballroom North
Session V – Immunotherapy
(Session Chair- Mark Febbraio) | Civic Ballroom South
15:00 - 15:30 [K16] Islet inflammation in type 2 diabetes: physiology, pathology, therapy
Marc Donath (co-organizer), University Hospital Basel, Switzerland
15:30–16:00 [K17] Targeting inflammation in patients with type 2 diabetes
Stephen Shoelson, Joslin Diabetes Center, USA
16:00–16:30 [K18] Islet autoimmunity in type 2 diabetes—more than just LADA
Jerry Palmer,  University of Washington, USA
16:30 - 17:00 Refreshment Break Simcoe & Dufferin Room and Civic Ballroom North
17:00–17:15 [O7] AMP-activated protein kinase (AMPK) links lipid metabolism with innate immunity and the therapeutic effects of salicylate  
M.D. Fullerton, McMaster University, Canada
17:15–17:45 [K19] Targeting immunometabolism: an interface between immune, metabolic and oncologic diseases
Dhavalkumar Patel, Novartis Institutes for BioMedical Research, Switzerland
17:45–18:00 [O8] Lipid uptake by adipose tissue macrophages improves glucose tolerance in obese mice
M. Aouadi, UMass Medical School, USA
18.00 – 18:15 Closing remarks Civic Ballroom South



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